Cd40 - CD40 antigen Gene

Also Known as IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21939

Summary

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein Ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to Other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd40 Products (4)

mRNA Protein Name
NM_011611.2 NP_035741.2 tumor necrosis factor receptor superfamily member 5 isoform 1 precursor
NM_170702.2 NP_733803.2 tumor necrosis factor receptor superfamily member 5 isoform 5 precursor
NM_170703.2 NP_733804.1 tumor necrosis factor receptor superfamily member 5 isoform 2 precursor
NM_170704.2 NP_733805.1 tumor necrosis factor receptor superfamily member 5 isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8910514 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell activation IDA
IDA: Inferred from direct assay
14594818 MGI
involved in B cell mediated immunity IGI
IGI: Inferred from genetic interaction
18624351 MGI
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of B cell proliferation IGI
IGI: Inferred from genetic interaction
15963492 MGI
involved in CD40 signaling pathway IGI
IGI: Inferred from genetic interaction
18624351 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
19047410 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within immune response-regulating cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
15240714 MGI
involved in immunoglobulin production IGI
IGI: Inferred from genetic interaction
18624351 MGI
acts upstream of interleukin-12 production IDA
IDA: Inferred from direct assay
15240714 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
21410936 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
16546095 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
8666928 MGI
acts upstream of or within positive regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
15963492 MGI
acts upstream of or within positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15240714 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IDA
IDA: Inferred from direct assay
12882831 MGI
acts upstream of or within regulation of immune response IDA
IDA: Inferred from direct assay
12882831 MGI
acts upstream of or within regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
12958312 MGI
Cellular Component GO Annotation Evidence References Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
located in cell surface IDA
IDA: Inferred from direct assay
20685650 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8566034 MGI
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
16708399 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20614026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 5

  • B-cell surface antigen CD40

  • CD40L receptor

  • T-cell differentiation antigen

Cd40 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cd40 P27512 Traf2 Mus musculus P39429
Anti Bait CoIP
23334419
Intra
Cd40 P27512 Btk Mus musculus P35991
Confocal
21441935
Intra
Cd40 P27512 Btk Mus musculus P35991
Anti Tag CoIP
21441935
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd40 Proteins

Cat. No. Product Name Accession Purity
HY-P72724 CD40 Protein, Mouse (HEK293, His) P27512-1 (L20-R193) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72911 CD40 Protein, Mouse (HEK293, Fc) P27512-1 (L20-R193) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74298 CD40 Protein, Mouse (Biotinylated , HEK293, His-Avi) P27512-1/NP_035741.2 (L20-R193) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9950 Omalizumab Inhibitor 99.70% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B1618 Corticosterone Agonist 99.77% Phase 3
HY-N6664 Gum arabic / Phase 3
Inhibitory Antibodies (22)
Cat. No. Product Name Effect
Purity Phase
HY-P99625 Frexalimab Inhibitor 99.00% Phase 3
HY-P99845 Dazodalibep 99.0% Phase 3
HY-P99842A Dapirolizumab Inhibitor 99.66% Phase 3
HY-P99046 Selicrelumab Agonist 99.29% Phase 2
HY-P99315 Ruplizumab Inhibitor 99.84% Phase 2
HY-P99742 Mitazalimab Inhibitor 99.23% Phase 2
HY-P99670 Iscalimab Inhibitor 99.64% Phase 2
HY-P99049 Sotigalimab Agonist 98.90% Phase 2
HY-P990726 Abiprubart 99.00% Phase 2
HY-P99257 Bleselumab Inhibitor 98.97% Phase 2
HY-P99701 Letolizumab Inhibitor 98.32% Phase 2
HY-P99167 Lucatumumab Inhibitor ≥99.0% Phase 2
HY-P99015 Dacetuzumab Inhibitor 95.37% Phase 2
HY-P99821 Ravagalimab Inhibitor 99.31% Phase 2
HY-P99572 Tecaginlimab Inhibitor 99.00% Phase 2
HY-P991525 2141-V11 Agonist 98.00% Phase 2
HY-P991510 CDX-1140 Agonist / Phase 2
HY-P991554 FFP-104 Modulator / Phase 2
HY-P991556 TQB2916 Agonist / Phase 2
HY-P991921 TNX-1500 Inhibitor / Phase 2
HY-P99325 Toralizumab Inhibitor 99.57% Phase 1
HY-P991666 BMS-986090 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122663A BIO8898 Inhibitor 98.77% Unkown
HY-120323 DRI-C21045 Inhibitor 98.11% Unkown
HY-110247 TRAF-STOP inhibitor 6877002 Inhibitor 99.67% Unkown
HY-148980A Polyinosinic acid sodium 91.5% Unkown
HY-154821A DRI-C21041 DIEA Inhibitor 99.07% Unkown
HY-131968 BMS-986202 Inhibitor 99.29% Unkown
HY-153345 Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br Agonist 99.67% Unkown
HY-49382 Fluocinolone acetonide 3-benzylaniline 99.93% Unkown
HY-154822 DRI-C25441 Inhibitor 99.53% Unkown
HY-118922 IW927 Inhibitor 99.23% Unkown
HY-152121 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal Agonist 95.68% Unkown
HY-122663 (Rac)-BIO8898 Inhibitor 98.03% Unkown
HY-16668 Tyrphostin A1 Inhibitor 98.96% Unkown
HY-125025 SMI 6860766 Inhibitor / Unkown
HY-154821 DRI-C21041 Inhibitor / Unkown
HY-D1236 Fluorescent brightener 71 Inhibitor / Unkown
HY-P10399 KGYY15 Inhibitor 99.19% Unkown
HY-148980 Polyinosinic acid / Unkown
HY-143410 Anti-inflammatory agent 16 Inhibitor / Unkown
HY-148459 ATAC21 / Unkown
HY-171590 SIK2-IN-3 Inhibitor / Unkown
HY-179701 NIK-IN-3 Inhibitor / Unkown
HY-D1124 Mordant brown 1 / Unkown
HY-D3334 PE-CF594 / Unkown
HY-P10937 AQP4 (205-215) / Unkown
HY-P10937A AQP4 (205-215) TFA / Unkown
HY-RS02246 CD40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02247 CD40LG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120471 AM-0687 Inhibitor / Unkown
HY-168384 M04 / Unkown
HY-174737 Human CD40LG mRNA / Unkown
HY-174738 Human CD40 mRNA / Unkown
HY-400878 Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal Agonist 99.86% Unkown
HY-RS16527 Cd40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17669 Cd40lg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22958 Cd40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24130 Cd40lg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990680 Anti-Mouse CD40 Antibody (FGK4.5/FGK45) Inhibitor 98.35% Unkown
HY-P990083 Tegoprubart Inhibitor 99.86% Unkown
HY-P990134 Anti-Mouse CD40L/CD154 Antibody (MR-1) Inhibitor 99.62% Unkown
HY-P990860 Anti-CD40 Antibody (G28.5) Inhibitor 95.00% Unkown
HY-P990133 Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Inhibitor 95.00% Unkown
HY-P990111 BMS-986325 (anti-CD40) Inhibitor 99.84% Unkown
HY-P991513 BI-655064 Inhibitor 98.56% Unkown
HY-P99321 Teneliximab Inhibitor ≥99.0% Unkown
HY-P991126 Ciltistotug Ligand 95.376% Unkown
HY-P99663 Inezetamab Inhibitor 99.77% Unkown
HY-P990269 Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) Inhibitor 95.00% Unkown
HY-P991086 MGD010 Inhibitor 99.06% Unkown
HY-P990270 Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) / Unkown
HY-P991460 Sym029 Agonist / Unkown
HY-P991555 XmAb5485 Inducer / Unkown
HY-P991557 ABI793 Inhibitor / Unkown
HY-P991918 KHK2840 Agonist / Unkown
HY-P991919 SBT-040 / Unkown
HY-P992408 MEDI-5083 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd40 NCBI NCBI:958